ABSTRACT Background Paraneoplastic dermatoses are rare, and about them there are no previous studies in the Cienfuegos province. The timely diagnosis of a possible internal neoplasm sometimes depends on its correct recognition. Objective to describe the behavior of paraneoplastic dermatoses in cancer patients. Methods descriptive study, carried out in patients with malignant neoplasms, treated from June 2016 to December 2017, at the Dr. Gustavo Aldereguía Lima Hospital, in Cienfuegos. Fifty-nine patients with paraneoplastic dermatosis were included, for which the type of dermatosis, time of appearance and its association with each type of neoplasia were analyzed. The information was obtained through the clinical dermatological examination and the medical records. Results 17 types of paraneoplastic dermatoses were identified, highlighting the Leser Trélat sign (21.0%), followed by Sweet's syndrome (16.1%) and pyoderma gangrenosum (11.3%). In 25 (42.4%) patients these were detected before the diagnosis of neoplasms, among which lymphoma (86.7%) was the most representative, followed by colon and breast neoplasms, although they were also associated with Syndrome of Sweet and a pyoderma gangrenosum. Conclusion Recognizing the characteristic lesions of paraneoplastic dermatoses facilitates the early detection of a hidden cancer, whose own manifestations would probably appear months later, even years.

RESUMEN Fundamento Las dermatosis paraneoplásicas son poco frecuentes, y acerca de ellas no existen estudios previos en la provincia de Cienfuegos. De su correcto reconocimiento depende en ocasiones el diagnóstico oportuno de una posible neoplasia interna. Objetivo describir el comportamiento de las dermatosis paraneoplásicas en pacientes oncológicos. Métodos estudio descriptivo, realizado en pacientes con neoplasias malignas, atendidos durante el período de junio de 2016 a diciembre de 2017, en el Hospital Dr. Gustavo Aldereguía Lima, de Cienfuegos. Fueron incluidos 59 pacientes con dermatosis paraneoplásicas, para los cuales se analizó tipo de dermatosis, momento de aparición y su asociación con cada tipo de neoplasia. La información se obtuvo a través del exámen clínico dermatológico y las historias clínicas. Resultados se identificaron 17 tipos de dermatosis paraneoplásicas, con destaque del signo Leser Trélat (21,0 %), seguido del Síndrome de Sweet (16,1 %) y el pioderma gangrenoso (11,3 %). En 25 (42,4 %) pacientes estas fueron detectadas antes del diagnóstico de neoplasias, entre las cuales el linfoma (86,7 %) fue la más representativa, seguido por las neoplasias de colon y mamas, aunque también se asociaron a Síndrome de Sweet y a pioderma gangrenoso. Conclusión Reconocer las lesiones características de las dermatosis paraneoplásicas facilita la detección precoz de un cáncer oculto, cuyas manifestaciones propias, probablemente, aparecerían meses después, incluso años.

This article estimates the Keynesian multiplier, disaggregating the effects of international tourism, for the case of Argentina. The purpose of the work is to observe the performance of the tourism sector in terms of its impact on the activity level of the economy. To calculate the multiplier, it has been based on the theoretical development presented by Bini & Masini (2008) for Romania, adapting to the particularities of the Argentina economy, and used the econometric method Simultaneous Equations. The decision to analyze the effects of international tourism, rather than domestic, is based on the conclusions presented by Haddad et al (2011) suggest that the multiplier effect of domestic tourism is neutral, being relevant only redistributive effect across regions.

Este artículo calcula el multiplicador keynesiano, aislando los efectos del turismo internacional para el caso de Argentina. La finalidad del trabajo consiste en observar el desempeño del sector turístico en términos de su impacto en el nivel de actividad de la economía en su conjunto. Para el cálculo del multiplicador se ha tomado como base el desarrollo teórico presentado por Bini & Masini (2008) para Rumania, adaptándolo a las particularidades de la economía argentina, y se ha utilizado el método econométrico de Ecuaciones Simultáneas. La decisión de analizar los efectos del turismo internacional, antes que el doméstico, se fundamenta en las conclusiones presentadas por Haddad et al. (2011) que sugieren que el efecto multiplicador del turismo doméstico es neutral, siendo relevantes únicamente los efectos redistributivos entre las regiones.

INTRODUCTION Hypertension and obesity in adults have been linked to increased EKG P-wave dispersion; the association has been shown in relation to hypertension, left ventricular hypertrophy and atrial enlargement. Though studies in children have linked P-wave dispersion to left ventricular hypertrophy, scant pediatric literature relates P-wave dispersion to hypertension and obesity. OBJECTIVE Assess the association of P-wave dispersion with blood pressure and nutritional status in a pediatric population. METHODS This cross-sectional study is part of the PROCDEC II project for pediatric hypertension diagnosis and control in Santa Clara, Cuba. Twelve-lead EKG and four blood pressure readings were conducted on a sample of 656 children aged 8-11 years. Blood pressure <90th percentile for age, sex and height was considered normal; 90th-95th percentile, prehypertension; and >95th percentile, hypertension. The main study variables were P-wave dispersion and systolic, diastolic and mean arterial pressure (MAP). Secondary variables were sex, height, weight, and body mass index. Comparisons of means, analysis of variance and linear correlations were done. RESULTS Mean P-wave dispersion differed significantly (p ≤0.05) among normotensive (30.10 ms), prehypertensive (32.99 ms) and hypertensive children (39.14 ms), as did mean MAP (p <0.05). P-wave dispersion and MAP were significantly correlated in prehypertensive and hypertensive children. Most overweight and obese children with high P-wave dispersion were prehypertensive or hypertensive. CONCLUSIONS Associations observed between P-wave dispersion and MAP in normotensive, prehypertensive and hypertensive children suggest potential for early detection of EKG patterns showing vulnerability. Given the relationship between increased P-wave dispersion and hypertension already described in adults, use of P-wave dispersion could be a simple, economical and noninvasive method of predicting risk of hypertensive cardiomyopathy in prehypertensive and hypertensive children; this in turn could guide timely, effective treatment and secondary prevention. Similar studies on a larger sample are needed to corroborate these results.

Background: Pancreatic infections during pancreatitis are caused by bacterial translocation of the intestinal flora into areas pancreatic necrosis. Thus, the main organisms involved are Echerichia coli in 25 to 35% of cases, Klebsiella spp in 10 to 25% and Enterobacter spp in 3% to 7%. Aim: To describe the microbiological features and antimicrobial sensitivity of pancreatic abscesses, operated at Temuco Regional Hospital. Materials and Methods: Subjects with a pancreatic abscess and operated in the surgical and emergency services of Temuco Regional Hospital between January 2004 and March 2005, were studied. The samples collected were incubated in blood and MacConkey agar plates. The in vitro sensitivity to antimicrobials was assessed using a qualitative method with sensidiscs for each antimicrobial. Results: Ten patients were studied. Serratia marcescens, Citrobacter freundii, Acinetobacter baumannii and Methicillin-Resistant Staphylococcus aureus were found, each in two cultures. Candida spp. was isolated from one culture. Forty percent of Gram-negative bacteria were sensitive to quinolones and all were sensitive to carbapenem. Conclusions: The most commonly isolated bacteria in pancreatic abscesses in our series were multiresistant gram-negative bacteria and Methicillin-Resistant Staphylococcus aureus

Introducción: El principal mecanismo involucrado en la infección pancreática es la translocación bacteriana de la flora intestinal a la necrosis pancreática lo que coincide con los organismos más frecuentemente encontrados: Escherichia coli (25%-35%), Klebsiella spp (10%-25%), Enterobacter spp (3%-7%). El objetivo del presente trabajo es describir la microbiología, la sensibilidad antibiótica de los gérmenes aislados y los esquemas antibióticos utilizados en una serie de pacientes con abscesos pancreáticos que fueron operados en el Hospital Regional de Temuco. Material y Método: estudio de serie de casos. Se incluyeron sujetos con diagnóstico de absceso pancreático, intervenidos quirúrgicamente en los servicios de cirugía y urgencias del Hospital Regional de Temuco en el período enero de 2004 a marzo de 2005. Los cultivos de las colecciones se siembran en agar sangre y agar Mac Conkey; la sensibilidad in vitro a los antibióticos se realiza por medio de método cualitativo con sensidiscos para cada tipo de antibiótico. Resultados: Se incluyeron 10 pacientes. Las bacterias más frecuentemente aisladas fueron Serratia marcescens, Citrobacter freundii, Acinetobacter baumannii y Estafiliococo aureus Meticilino Resistente (SAMR) cada una presente en 2 cultivos. Se aisló en 1 cultivo Candida spp. Las bacterias gram negativas fueron sensibles a las quinolonas en 40% y todas fueron sensibles a los carbapenem. Conclusiones: La microbiología de los abscesos pancreáticos presenta un cambio en relación a los reportes previos de la literatura. Las bacterias más frecuentemente aisladas en los abscesos pancreáticos de nuestra serie son bacterias gramnegativas multiresistentes y SAMR. El esquema antibiótico más frecuente fue la combinación de carbapenem y vancomicina en 5 pacientes